Diagnostics of chronic lymphocytic leukemia

Abstract:

Clinical and laboratory methods have a crucial role in establishing the diagnosis and the choice of the optimal therapy for patients with chronic lymphocytic leukemia (CLL). The Croatian (CroHem) guidelines are aligned with international standards due to advanced laboratory diagnostics and the availability of novel therapies in Croatia. Elementary diagnostic methods are complete, including differential blood count, peripheral blood smear, immunophenotyping, and molecular tests. By analyzing the mutational status of IGHV and TP53 genes, along with the detection of chromosomal abnormalities, it is possible to make a precise diagnosis and determine the patient‘s prognosis. These methods provide a personalized therapeutic approach and improve the treatment of CLL patients.

Key words:
chronic lymphocytic leukemia; flow cytometry; fluorescence in situ hybridization (FISH); next-generation sequencing (NGS)