MEDIX, God. 16 Br. 89/90  •  Sponzorirani članak  •  Pulmologija HR ENG

Praktične implikacije sekundarnih analiza ispitivanja UPLIFTSecondary analyses of the UPLIFT trial: practical implications

Neven Tudorić

Nedavno publicirani rezultati analiza specifičnih skupina bolesnika u ispitivanju UPLIFT (Understanding potential long-term impact on function with tiotropium), koje je obuhvatilo bolesnike s blažim oblikom KOPB-a, bolesnike bez trajne terapije održavanja, te bolesnike mlađe od 50 godina, evidentno pokazuju da je tiotropij značajno učinkovitiji upravo u tih bolesnika. Prihvaćajući ova saznanja te imajući na umu da je slabljenje plućne funkcije brže upravo u ranim stupnjevima bolesti, evidentna je potreba ranog dijagnosticiranja KOPB-a i pravovremenog uvođenja terapije. 

Ključne riječi:
KOPB; rano liječenje; tiotropij

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Recently published results of secondary analyses of specific subgroups of patients participating in the UPLIFT trial (patients with moderate chronic obstructive pulmonary disease [COPD], “maintenance-free” patients, patients aged less than 50 years) showed that tiotropium was significantly more effective particularly in these patients. In addition, there is evidence that, in contrast to conventional thinking, decline of lung function occurs at a considerably faster rate in the early stages of the disease. These facts indicate the need for early diagnosis and timely, intensive intervention in COPD.  

Key words:
pulmonary disease, chronic obstructive; therapy; tiotropium